jueves, 17 de septiembre de 2015

Tratamientos antioxidantes



Si vas a comenzar un tratamiento antioxidante, lo primero que debes tener en cuenta son las directivas dadas por el Grupo de Perth. Se pueden leer aquí.

Podría ser bastante difícil conseguir que te midan el estado redox, pero podrías querer seguir un tratamiento antioxidante en cualquier caso. Voy a facilitarte entonces información que podría serte útil acerca de qué antioxidantes tomar, en qué dosis y durante cuánto tiempo. Siento que dicha información esté de momento en inglés.


En primer lugar, te sugiero que tengas en cuenta estos dos importantes estudios, en los que se trató a los pacientes con N-acetilcisteína (NAC):

Glutathione deficiency is associated with impaired survival in HIV disease

Artículo completo aquí.

N-acetylcysteine replenishes glutathione in HIV infection

Artículo completo aquí.



Sin embargo, el Grupo de Perth hace ciertas críticas a estos estudios, diciendo que la mejora en la supervivencia podría haber sido aún mucho mejor. Se puede leer aquí.

Por ejemplo:

It appears the Herzenbergs were not aware of a number of significant factors:

1.The glutathione –SH are not the –SH which determine cellular functioning.

2. There are laboratory methods to measure cellular redox which should be used to adjust the dose of –SH compounds for individual patients;

3. AIDS patients and those at risk are exposed to many oxidising agents other than alcohol and paracetamol.





A continuación, mencionar el siguiente enlace

donde podemos leer:


Dosage

The best dose of NAC for people with HIV is not clear, but reviewing the data from clinical trials in people with HIV may be useful. In the previously mentioned American study, use of about 4 grams per day of NAC was associated with improved survival. However, anecdotal reports suggest that taking such large doses of NAC for prolonged periods could cause abdominal discomfort, nausea, vomiting and diarrhea.

According to results from two German studies, a dose of 3 grams every other day is effective at increasing GSH levels and does not appear to cause toxicity. Alternatively, some people with HIV take smaller doses of NAC, between 500 to 1,000 mg, twice daily.

Taking NAC with meals may reduce nausea. The manufacturer of the liquid form of NAC suggests that when it is taken in high doses it can be mixed with cola drinks or fruit juice to reduce the risk of nausea.


Side effects

At high doses, NAC may cause the following symptoms in some people:

nausea
abdominal discomfort
vomiting
diarrhea

In lab experiments with cells, high concentrations of NAC can weaken some activities of the immune system. There have been no studies of this in people.


Drug interactions

If you are taking antibiotics, NAC should not be taken, as it will weaken their beneficial effects.